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  Pharmacy CE
ACPE Accredited Continuing Education for Pharmacists and Pharmacy Technicians

A Time and “-plase” for Everything: Updated Management of Acute Ischemic Stroke Webcast – 1 CE

Activity Overview

Alteplase and tenecteplase are commonly utilized within health-systems requiring rapid decision-making by the healthcare team. These medications include high risk of life-threatening side effects for which patients must be carefully chosen. Pharmacists must be consistently ready to review orders for appropriateness. Recent literature search revealed updates in the timing and dosing scheme related to the use of alteplase for acute ischemic stroke. 2019 Stroke guidelines added a new section on tenecteplase, highly likely to be a new concept among many pharmacists practicing outside of neurology. Endovascular thrombectomy for acute ischemic stroke is a growing topic in neurology and Pharmacists should have a basic understanding of the process and timing of this procedure to understand how to select pharmacotherapy. This activity will be a knowledge-based activity outlining key principles related to the mechanism of action of fibrinolytic therapy (alteplase, tenecteplase) so the audience understands the background of the disease state and our pharmacotherapy goals. A thorough literature review will be provided to understand the efficacy and timing of these agents. A focus on tenecteplase will be provided as this may be very new to many pharmacists since the literature is only about 5 years old. Endovascular procedures will be discussed so pharmacists can visualize the process of selecting patients and the outcomes associated with this therapy. Multiple choice questions will be asked throughout to engage the audience and assess understanding.

Pharmacist Learning Objectives

At the conclusion of this continuing education activity, the participant will be able to:

  1. Explain the mechanism of action of tissue plasminogen activator in a medical emergency
  2. Review literature regarding the best practice for use of alteplase and tenecteplase for acute ischemic stroke
  3. Outline the use of endovascular mechanical thrombectomy for acute ischemic stroke

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Accreditation Statement

ACPEAchieveCE is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

AchieveCE is also accredited by the Florida Board of Pharmacy (provider no. 50-20641). This course is approved by CE Broker, with CE Broker No. 20-845769.

Faculty Information

David Peters, PharmD, BCCCP is an assistant professor and clinical pharmacist in the Dayton, Ohio area. He completed his PharmD at Ohio Northern University and his residency training at the University of Cincinnati Medical Center. He has held a variety of roles while employed for the Cedarville University School of Pharmacy, including coordination of the Renal Module and Critical Care elective and course participation related to critical care topics. He holds a practice site in the Neuroscience Intensive Care Unit at Miami Valley Hospital where he coordinates pharmaceutical care for patients and provides pharmacology education for both pharmacy and medical learners. His projects include optimization of stroke and epilepsy pharmacology and he has served on multiple process improvement and research projects

Financial Support Disclosure

This activity was developed by AchieveCE free of any commercial support. Dr. David Peters, has no actual or potential conflicts of interest to disclose.

Content Complexity

  Level 2. Basic Application of Skills and Concepts

Delivery Type

Home Study Webcast



1.0 Contact Hours


Disease State Management/Drug Therapy

Target Audience


Activity Type


Universal Activity Number


Activity Release Date

July 9, 2021

Activity Expiration Date

July 9, 2024

Handout Download Link(s)



Requirements for Credit

Participants must score a passing grade of 70% or higher on the activity post-test and complete an activity evaluation. There are no time limits and unlimited test-taking attempts. Credits will be reported automatically to CPE Monitor and/or CE Broker if your license information is entered properly in your profile.

CE Broker Reporting

If you are licensed under a board supported by CE Broker, feel free to log into your CE Broker account to view your reported courses or to contact their support staff.

Hardware Requirements

Windows 8.1, Windows 10
Mac OS X 10.1 or higher
iOS 10+, Android 4.3+

Software Requirements

Google Chrome, Microsoft Edge, Mozilla Firefox
Adobe Acrobat Reader

Network Requirements

Broadband Internet Connection:
T1, Hi-speed DSL or Cable
4G cellular connection

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